Radiosensitization with Gadolinium Chelate-Coated Gold Nanoparticles Prevents Aggressiveness and Invasiveness in Glioblastoma.

Maxime Durand,Alicia Chateau,Justine Jubréaux,Jérôme Devy, Héna Paquot,Gautier Laurent,Rana Bazzi,Stéphane Roux,Nicolas Richet, Aurélie Reinhard-Ruch,Pascal Chastagner,Sophie Pinel

International journal of nanomedicine（2023）

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摘要

Combining Au@DTDTPA(Gd) nanoparticles and X-ray radiotherapy appears as an attractive therapeutic strategy to decrease number, viability and aggressiveness of tumor cells that escape and can invade the surrounding brain parenchyma. Hence, Au@DTDTPA(Gd)-enhanced radiotherapy opens up interesting perspectives for glioblastoma treatment.

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关键词

brain tumor,cancer cell invasion,gold nanoparticles,radiotherapy,tumor recurrence

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