Non-covalent strategies to functionalize polymeric nanoparticles with NGR peptides for targeting breast cancer
International Journal of Pharmaceutics(2023)
摘要
•Polymeric NPs functionalized with NGR peptides to target breast cancer are developed.•Targeting peptides are anchored on NP surface through two non-covalent binding strategies.•The uptake of NPs in MDA-MB231 cancer cells is mediated by Neuropilin-1 receptor.•Targeted NPs loaded with docetaxel are more cytotoxic than free drug.•Targeted NPs show superior activity in a mice model of breast cancer.
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关键词
Polymeric nanoparticles,NGR peptides,Palmitoylation,Breast cancer
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