4-Iodo-6-phenylpyrimidine (4-IPP) suppresses fibroblast-like synoviocyte- mediated inflammation and joint destruction associated with rheumatoid arthritis

Weiwei Sun,Jinquan Ma,Minhao Chen,Weidong Zhang,Chunxiang Xu, Yunyi Nan,Weijie Wu,Xingxing Mao,Xi Cheng,Hao Cai,Jianhua Zhang,Hua Xu,Youhua Wang

International Immunopharmacology（2023）

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摘要

•We have successfully fabricated the 4-IPP/PLGA/Nanospheres.•Nanoparticles enhanced drug delivery and control drug release.•The nanospheres achieved the inhibition of bone and cartilage destruction.

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关键词

Rheumatoid arthritis,4-IPP,Fibroblast-like synovial cells,Nanospheres,MAPKs

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