RGD-decorated PLGA nanoparticles improved effectiveness and safety of cisplatin for lung cancer therapy

•This study translates the development of RGD decorated PLGA nanoparticles to deliver bioactive molecules.•Cisplatin and upconversion nanoparticles were co-delivered via PLGA nanoparticles.•Developed formulationed were characterized and results were interpreted in terms of physicochemical properties and pharmacokietics.•The efficacy and safety of cisplatin were proved through hemolysis in human blood, histopathology and biochemical estimation in rats.•The developed formulation may produce potential effects of CDDP loaded cargoes in in-vitro and in-vivo models.