Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma.

Mary K McKenna,Ada Ozcan,Daniel Brenner,Norihiro Watanabe,Maureen Legendre,Dafydd G Thomas,Christopher Ashwood,Richard D Cummings,Challice Bonifant,David M Markovitz,Malcolm K Brenner

Journal for immunotherapy of cancer（2023）

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摘要

T cells expressing H84T CAR target malignant cells and their stroma in PDAC tumor models. The incorporation of glycan-targeting lectins within CARs thus extends their activity to include both malignant cells and their supporting stromal cells, disrupting the TME that otherwise diminishes the activity of cellular therapies against solid tumors.

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关键词

Receptors, Chimeric Antigen,Tumor Microenvironment

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