Association of G protein-coupled receptor 78 with salivary dysfunction in male Sjögren's patients.

Tsutomu Tanaka,Maria C Guimaro,Hiroyuki Nakamura,Paola Perez,Youngmi Ji,Drew G Michael,Sandra A Afione,Changyu Zheng,Corinne Goldsmith,William D Swaim,Anne Marie Lynge Pedersen,John A Chiorini

Oral diseases（2023）

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摘要

GPR78 overexpression can induce apoptosis and salivary gland hypofunction in male mice through lysosomal dysfunction and increased caspase-dependent apoptosis in salivary gland epithelium, which may drive disease in humans.

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关键词

GPR78,Sjögren's syndrome,apoptosis,lysosome,sex hormone

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