Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma.

Jack L Williams,Chris Smith,Charlotte Hall,Zakaa Khaled,Avinaash Maharaj,Ruth Kwong,James Pittaway,Josefina Casas,Laila Parvanta,Tarek Ezzat Abdel-Aziz,Fausto Palazzo,Teng-Teng Chung,Leonardo Guasti,Lou Metherell,Rathi Prasad

European journal of endocrinology（2023）

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摘要

We, therefore, propose that SGPL1-overexpressing ACC tumours reduce patient survival by increasing fuel usage for anabolism and energy production to facilitate growth and invasion.

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关键词

SGPL1,adrenocortical carcinoma,sphingolipids,sphingosine-1-phosphate lyase

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