Brain endothelium-derived extracellular vesicles containing amyloid-beta induce mitochondrial alterations in neural progenitor cells.

Olivia M Osborne, Jennifer M Kowalczyk, Kelssey D Pierre Louis,Manav T Daftari,Brett M Colbert,Oandy Naranjo,Silvia Torices,Ibolya E András,Derek M Dykxhoorn,Michal Toborek

Extracellular vesicles and circulating nucleic acids（2022）

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摘要

Aim:Elevated brain deposits of amyloid beta (Aβ 404040Methods:Endothelial EVs were derived from an in vitro40Results:We demonstrate that physiological concentrations of Aβ 40Conclusion:Intercellular transfer of Aβ 40

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关键词

Alzheimer’s disease,Blood-brain barrier,Seahorse,extracellular vesicle,mitochondrial bioenergetics,neural progenitor cell,neurogenesis

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