Models for Evidence Generation During the COVID-19 Pandemic: New Opportunities for Clinical Trials in Cardiovascular Medicine.

HomeCirculationVol. 147, No. 3Models for Evidence Generation During the COVID-19 Pandemic: New Opportunities for Clinical Trials in Cardiovascular Medicine No AccessArticle CommentaryRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessArticle CommentaryRequest AccessFull TextModels for Evidence Generation During the COVID-19 Pandemic: New Opportunities for Clinical Trials in Cardiovascular Medicine Patrick R. Lawler Patrick R. LawlerPatrick R. Lawler Correspondence to: Patrick R. Lawler, MD, MPH, Peter Munk Cardiac Center, Toronto General Hospital, RFE3-410, 190 Elizabeth St, Toronto, ON, Canada M5G 2C4. Email: E-mail Address: [email protected] https://orcid.org/0000-0001-5155-5071 Peter Munk Cardiac Centre, Toronto General Hospital; and Division of Cardiology and Interdepartmental Division of Critical Care Medicine, University of Toronto, Canada. Search for more papers by this author Originally published17 Jan 2023https://doi.org/10.1161/CIRCULATIONAHA.122.061231Circulation. 2023;147:187–189FootnotesThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.Circulation is available at www.ahajournals.org/journal/circFor Sources of Funding and Disclosures, see page 189.Correspondence to: Patrick R. Lawler, MD, MPH, Peter Munk Cardiac Center, Toronto General Hospital, RFE3-410, 190 Elizabeth St, Toronto, ON, Canada M5G 2C4. Email: patrick.[email protected].caReferences1. Libby P. The changing landscape of atherosclerosis.Nature. 2021; 592:524–533. doi: 10.1038/s41586-021-03392-8CrossrefMedlineGoogle Scholar2. Lawler PR, Hochman JS, Zarychanski R. What are adaptive platform clinical trials and what role may they have in cardiovascular medicine?Circulation. 2022; 145:629–632. doi: 10.1161/circulationaha.121.058113LinkGoogle Scholar3. Park JJH, Detry MA, Murthy S, Guyatt G, Mills EJ. How to use and interpret the results of a platform trial: users’ guide to the medical literature.JAMA. 2022; 327:67–74. doi: 10.1001/jama.2021.22507CrossrefMedlineGoogle Scholar4. Dodd LE, Freidlin B, Korn EL. Platform trials - beware the noncomparable control group.N Engl J Med. 2021; 384:1572–1573. doi: 10.1056/NEJMc2102446CrossrefMedlineGoogle Scholar5. ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators. Therapeutic anticoagulation with heparin in noncritically ill patients with COVID-19.N Engl J Med. 2021; 385:790–802. doi: 10.1056/NEJMoa2105911CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsCited By Szekely Y, Gilead R, Réa A and Lawler P (2023) An evolving understanding of the basis and management of vascular complications of COVID-19: Where do we go from here?, Canadian Journal of Cardiology, 10.1016/j.cjca.2023.03.019, Online publication date: 1-Mar-2023. Godoy L, Farkouh M, Zarychanski R and Lawler P (2023) The Impact of COVID-19 Research on the Development of Scalable Frameworks for Efficient Clinical Trials in Cardiovascular Medicine, Canadian Journal of Cardiology, 10.1016/j.cjca.2023.03.010, Online publication date: 1-Mar-2023. January 17, 2023Vol 147, Issue 3 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.122.061231PMID: 36649393 Originally publishedJanuary 17, 2023 KeywordspandemicsCOVID-19clinical trialPDF download Advertisement SubjectsClinical Studies