Dynamic Mutational Landscape of Cerebrospinal Fluid Circulating Tumor DNA and Predictors of Survival after Proton Craniospinal Irradiation for Leptomeningeal Metastases.

N Ari Wijetunga,Alexander G Goglia,Nils Weinhold,Michael F Berger,Michael Cislo,Daniel S Higginson,Kiana Chabot,Ahmed M Osman,Lauren Schaff,Elena Pentsova,Alexandra M Miller,Simon N Powell,Adrienne Boire,Jonathan T Yang

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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摘要

In patients with solid tumor LM undergoing pCSI, we found unique genomic profiles associated with pCSI through CSF ctDNA analyses. Patients with reduced genomic diversity within the leptomeningeal compartment demonstrated improved OS after pCSI suggesting that CSF ctDNA analysis may have use in predicting pCSI response.

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