Metabolic landscape dysregulation in bronchoalveolar lavage fluid of checkpoint inhibitor pneumonitis

Wenyi Yu,Yukun He,Ying Shang,Tiantian Guo,Keqiang Wang,Hongge Liang,Jianbo Xue,Xinqian Ma,Xinlin Mu,Ran Li,Zhancheng Gao

Clinical Immunology（2023）

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摘要

•Relative LC and IPF, CIP is associated with an intermediate metabolic profile.•Tumor-associated glycosylation is suppressed in patients with CIP.•Dysregulated polyamines and lipids contribute to inflammatory environment in CIP.•CD8+ T cells in the BALF of CIP patients correlate with enriched metabolites.

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关键词

Lung cancer,Checkpoint inhibitor pneumonitis,Idiopathic pulmonary fibrosis,Bronchoalveolar lavage fluid,Metabolomics analysis,Flow cytometry

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