Mitochondrial DNA: a novel indicator of active inflammation in ANCA-associated vasculitides.

Stavros Giaglis,Douglas Daoudlarian,Jens Thiel,Marta Rizzi,Diego Kyburz,Nils Venhoff,Ulrich A Walker

Rheumatology (Oxford, England)（2023）

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摘要

mtDNA, unlike nDNA, is elevated in the plasma of AAV patients and may contribute to systemic inflammation. mtDNA could be superior to established biomarkers in the laboratory monitoring of AAV activity.

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关键词

ANCA-associated vasculitis,disease activity,innate immunity,mitochondrial DNA,neutrophil extracellular traps

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