Carrier protein mediated cargo sensing in quorum signal synthases.

Patrick D Fischer, Abu Sayeed Chowdhury,Thomas Bartholow,Shibani Basu, Eric Baggs, Huel S Cox,Srđan Matošin,Michael D Burkart,Lisa Warner,Rajesh Nagarajan,Haribabu Arthanari

Chemical communications (Cambridge, England)（2023）

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摘要

Acyl-homoserine lactone synthases make specific AHL quorum sensing signals to aid virulence in Gram-negative bacteria. Here, we use solution NMR spectroscopy to demonstrate that the carrier protein-enzyme interface accurately reveals substrate recognition mechanisms in two quorum signal synthases.

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