Design, synthesis and bio-evaluation of indolin-2-ones as potential antidiabetic agents.

Diabetes mellitus is a serious global health concern, and this is expected to impact more than 300 million people by 2025. The current study focuses on identifying substituted indolin-2-one-based inhibitors for two indispensable drug targets, α-amylase and α-glucosidase. The structures of synthetic compounds were confirmed by spectroscopic techniques and evaluated for enzyme inhibition activities. Kinetic and studies were also performed. All compounds exhibited good-to-moderate inhibitory potential. Most importantly, compounds , , , and were identified as potent α-glucosidase inhibitors (IC = 9.15 ± 0.12-13.74 ± 0.12 μM). This study identified that these synthetic compounds might serve as potential lead molecules for antidiabetic agents.