Development of an LC-MRM-MS-Based Candidate Reference Measurement Procedure for Standardization of Serum Apolipoprotein (a) Tests.

L Renee Ruhaak,Fred P H T M Romijn,Ilijana Begcevic Brkovic,Zsusanna Kuklenyik,Julia Dittrich,Uta Ceglarek,Andrew N Hoofnagle,Harald Althaus,Eduardo Angles-Cano,Stefan Coassin,Vincent Delatour,Liesbet Deprez,Ioannis Dikaios,Gerhard M Kostner,Florian Kronenberg,Alicia Lyle,Urban Prinzing,Hubert W Vesper,Christa M Cobbaert

Clinical chemistry（2023）

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摘要

A robust, antibody-independent, MS-based cRMP was developed as higher order RMP and an essential part of the apo(a) traceability chain and future RMS. The cRMP fulfils predefined analytical performance specifications, making it a promising RMP candidate in an SI-traceable MS-based RMS for apo(a).

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关键词

serum apolipoprotein,candidate reference measurement procedure,lc-mrm-ms-based

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