SPARC promotes fibroblast proliferation, migration, and collagen production in keloids by inactivation of p53.

Shanshan Shi,Qiuchen Li,Yanxin Liu,Rui Zhang,Huaxia Chen

Journal of dermatological science（2023）

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摘要

Fibroblast proliferation, migration, and ECM synthesis were promoted by SPARC overexpression, which was achieved by regulating the p53 pathway. Our findings provide new therapeutic targets for keloids.

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关键词

Cell proliferation,ECM synthesis,Fibroblast,Keloids,SPARC

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