Radiation to all macroscopic sites of tumor permits greater systemic antitumor response to in situ vaccination.

Peter M Carlson,Ravi B Patel,Jen Birstler, Matthew Rodriquez, Claire Sun,Amy K Erbe,Amber M Bates,Ian Marsh,Joseph Grudzinski,Reinier Hernandez,Alexander A Pieper,Arika S Feils,Alexander L Rakhmilevich,Jamey P Weichert,Bryan P Bednarz,Paul M Sondel,Zachary S Morris

Journal for immunotherapy of cancer（2023）

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摘要

We report a novel use for low-dose RT, not as a direct antitumor modality but as an immunomodulator capable of driving and expanding antitumor immunity against metastatic tumor sites following ISV.

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关键词

Immunotherapy,Radiotherapy,Tumor Microenvironment

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