APOE Genotype Modifies the Association of Fusiform Gyrus Cerebral Metabolic Rate of Oxygen Consumption and Object Naming Performance.

Chelsea C Hays Weeks,Zvinka Z Zlatar, M J Meloy,David D Shin,Liu Thomas,Christina E Wierenga

Journal of Alzheimer's disease : JAD（2023）

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摘要

Results suggest that the relationship between neural function and cognition is altered among older adult APOEɛ4 carriers prior to the onset of dementia, implicating CMRO2 response as a potential mechanism to support cognition in APOE-related AD risk.

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APOEɛ4,Aging,Alzheimer’s disease,calibrated fMRI,cerebral blood flow,cognition,cognitive decline,metabolism

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