Rapid-eye-movement sleep, neurodegeneration and amyloid deposition in ageing.

Claire André,Pierre Champetier,Stéphane Rehel,Elizabeth Kuhn,Edelweiss Touron,Valentin Ourry,Brigitte Landeau,Gwendoline Le Du,Florence Mézenge,Shailendra Segobin,Vincent de la Sayette,Denis Vivien,Gaël Chételat,Géraldine Rauchs

Annals of neurology（2023）

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摘要

These results suggest that alterations of REM sleep microstructure are associated with greater neurodegeneration and neocortical amyloid deposition in older adults. Further studies are warranted to replicate these findings and determine whether older adults exhibiting REM sleep alterations are more at risk of cognitive decline and belonging to the Alzheimer's continuum. This article is protected by copyright. All rights reserved.

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amyloid deposition,neurodegeneration,aging,eye

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