Protective effect of Eprosartan against ischemic acute renal injury: Acting on NF-κB, caspase 3, and Sirtuin 1

Behzad Lotfi,Yasin Bagheri,Abdollah Abdollahpour,Elham Ahmadian,Samira Matin,Amirhossein Firouzfar,Sepideh Zununi Vahed,Fateme Khajepour

International Immunopharmacology（2023）

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摘要

•Eprosartan decreases NF‐κB and its downstream pro‐inflammatory cytokines as an anti‐inflammatory drug.•Eprosartan changes levels of Sirtuins and apoptotic factors like caspases‐3 as an anti-apoptotic agent.•Eprosartan could improve renal function by protecting the kidneys against I/R damages.

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关键词

Ischemia/reperfusion injury,Acute kidney injury,Mitochondria,Eprosartan,Angiotensin II receptor antagonist

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