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Design and Synthesis of 6-Methylpyridin-2-one Derivatives As Novel and Potent GluN2A Positive Allosteric Modulators for the Treatment of Cognitive Impairment

Takafumi Yukawa,Tohru Yamashita,Toshihiro Imaeda,Hiroyuki Kakei, Shogo Hashizume,Minoru Nakamura,Masaki Daini,Atsutoshi Okabe,Kosuke Nakashima,Akina Harada,Naohiro Narita,Ezio Bettini,Annarosa Ugolini,Mauro Corsi,Tomoaki Hasui

BIOORGANIC & MEDICINAL CHEMISTRY（2023）

Cited 0|Views10
Key words
N -methyl-D-aspartate receptor (NMDAR),GluN2A positive allosteric modulator (PAM),6-methylpyridin-2-one,Long-term potentiation (LTP)
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