Single-cell RNA-seq reveals cellular heterogeneity from deep fascia in patients with acute compartment syndrome.

Tao Wang,Yubin Long,Lijie Ma,Qi Dong,Yiran Li,Junfei Guo,Lin Jin,Luqin Di,Yingze Zhang,Ling Wang,Zhiyong Hou

Frontiers in immunology（2022）

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摘要

We identified a high stress-specific subcluster and variations in immune cells and fibroblast subclusters, as well as their differentially expressed genes, in ACS patients. Our findings reveal the functions of the deep fascia in the pathophysiology of ACS, providing new approaches for its treatment and prevention.

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关键词

acute compartment syndrome,fibroblast,heat shock protein,immune cell,single cell RNA seq

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