Shared functional network abnormality in patients with temporal lobe epilepsy and their siblings.

Kangrun Wang,Fangfang Xie,Chaorong Liu,Ge Wang,Min Zhang,Jialinzi He,Langzi Tan,Haiyun Tang,Fenghua Chen,Bo Xiao,Yanmin Song,Lili Long

CNS neuroscience & therapeutics（2023）

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摘要

Patients with temporal lobe epilepsy and their unaffected siblings showed shared topological functional disturbance and the effective functional network connectivity impairment. These abnormalities may contribute to the pathogenesis that promotes the susceptibility of seizures and language decline in temporal lobe epilepsy.

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关键词

endophenotype,functional magnetic resonance imaging,graph theory,independent component analysis,temporal lobe epilepsy

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