Runt-related transcription factor-1 ameliorates bile acid-induced hepatic inflammation in cholestasis through JAK/STAT3 signaling.

Liangjun Zhang,Qiong Pan,Lu Zhang,Haihan Xia,Junwei Liao,Xiaoxun Zhang,Nan Zhao,Qiaoling Xie,Min Liao,Ya Tan,Qiao Li,Jinfei Zhu,Ling Li,Shijun Fan,Jianwei Li,Chengcheng Zhang,Shi-Ying Cai,James L. Boyer,Jin Chai

Hepatology (Baltimore, Md.)（2023）

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摘要

This study has gained initial evidence establishing the functional role of hepatocyte RUNX1 in alleviating liver inflammation during cholestasis through JAK/STAT3 signaling. Modulating hepatic RUNX1 activity could be a new therapeutic target for cholestasis.

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关键词

hepatic inflammation,bile acid–induced,cholestasis,jak/stat3,runt-related

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