Enhanced glaucomatous damage accompanied by glial response in a new multifactorial mouse model.

Sabrina Reinehr,Renée M Girbig,Kim K Schulte,Janine Theile, M Ali Asaad,Rudolf Fuchshofer,H Burkhard Dick,Stephanie C Joachim

Frontiers in immunology（2022）

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摘要

In this new model, an additive degeneration could be noted in optic nerves as well as in the number of RGCs. These results suggest a potential additive role of high IOP and immune factors in glaucoma development, which will aid for understanding this multifactorial disease more precisely in the future.

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关键词

autoimmune glaucoma,combination,glia,intraocular pressure,microglia,myelin,optic nerve,retinal ganglion cells

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