The influence of flip-flop in population pharmacokinetic analyses.
CPT: pharmacometrics & systems pharmacology(2023)
摘要
Flip-flop is a term used to describe the scenario where the rate constants for multiexponential models appear to be switched. However, in reality, it is a permutation of the rank order of the parameter values. In this perspective, we revisit flip-flop pharmacokinetics and discuss its influence in population pharmacokinetic analyses.
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关键词
population
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