The P2X7 receptor contributes to seizures and inflammation-driven long-lasting brain hyperexcitability following hypoxia in neonatal mice.

Jonathon Smith,Aida Menéndez Méndez,Mariana Alves,Alberto Parras,Giorgia Conte,Anindya Bhattacharya,Marc Ceusters,Annette Nicke,David C Henshall,Eva M Jimenez-Mateos,Tobias Engel

British journal of pharmacology（2023）

引用 6|浏览11

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摘要

Treatments based on targeting the P2X7R may represent a novel therapeutic strategy for neonatal seizures with P2X7Rs contributing to the generation of neonatal seizures, driving inflammatory processes and long-term hyperexcitability states.

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关键词

P2X7 receptor,inflammation,neonatal seizures,purinergic signalling

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