Decitabine enhances the tumoricidal potential of TRAIL via the epigenetic regulation of death receptor 4 in gastric cancer.

Lin Li, Qian Niu,Yuanmin Zhu,Biao Fan,Guibin Yang

Journal of gastrointestinal oncology（2022）

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摘要

Decitabine enhances the effect of TRAIL by inhibiting the growth and inducing the apoptosis of GC cells. This is achieved by the epigenetic modification of decitabine, which upregulates DR4. Decitabine may act as a sensitizing agent of TRAIL. The combined use of decitabine and TRAIL may provide a novel idea for GC treatment.

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关键词

Decitabine,death receptor 4 (DR4),gastric cancer (GC),methylation,tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

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