α-Cyperone protects dopaminergic neurons and inhibits neuroinflammation in LPS-induced Parkinson’s disease rat model via activating Nrf2/HO-1 and suppressing NF-κB signaling pathway

Bingxu Huang,Guiqiu Hu,Xiaofeng Zong,Shuo Yang,Dewei He,Xiyu Gao,Dianfeng Liu

International Immunopharmacology（2023）

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摘要

•α-Cyperone exerts neuroprotective effects in LPS-induced Parkinson’s disease rat model.•α-Cyperone alleviates dopaminergic neurodegeneration by inhibiting neuroinflammation and oxidative stress.•α-Cyperone’s protective effect is via activating Nrf2/HO-1 and suppressing NF-κB signaling pathway.

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关键词

α-Cyperone,Parkinson's disease,Neuroinflammation,Oxidative stress,Nrf2

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