Trastuzumab emtansine vs lapatinib and capecitabine in HER2-positive metastatic breast cancer brain metastases: A real-world study

Thibaut Sanglier,Jinjoo Shim, Neil Lamarre, Claudia Peña-Murillo,Vincent Antao,Filippo Montemurro

The Breast(2023)

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摘要
•Breast cancer with brain metastases (BCBM) has been associated with lower survival.•T-DM1 improves survival vs lapatinib + capecitabine in real-world HER2+ BCBM patients.•Time to next treatment was also prolonged with T-DM1 vs lapatinib + capecitabine.•T-DM1 is an effective and clinically relevant option for patients with HER2+ BCBM.
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关键词
Trastuzumab emtansine,HER2-Positive metastatic breast cancer,Brain metastases,Lapatinib plus capecitabine,Real-world
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