GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells.

Morten S Hansen,Kent Søe,Line L Christensen,Paula Fernandez-Guerra,Nina W Hansen,Rachael A Wyatt,Claire Martin,Rowan S Hardy,Thomas L Andersen,Jacob B Olesen,Bolette Hartmann,Mette M Rosenkilde,Moustapha Kassem,Alexander Rauch,Caroline M Gorvin,Morten Frost

European journal of endocrinology（2023）

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摘要

GIP inhibits bone resorption and improves survival of human osteoblasts, indicating that drugs targeting GIPR may impair bone resorption, whilst preserving bone formation.

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关键词

Akt1/2,GIPR,NFATc1,NFκB,bone remodeling,c-Src,osteoporosis,resorption

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