SCN9A variant in a family of mixed breed dogs with congenital insensitivity to pain.

Rodrigo Gutierrez-Quintana,Matthias Christen,Kiterie M E Faller,Julien Guevar,Vidhya Jagannathan,Tosso Leeb

Journal of veterinary internal medicine（2023）

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摘要

We confirmed the diagnosis of CIP in a family of mixed breed dogs and identified a likely pathogenic variant in the SCN9A gene. The clinical signs observed in these dogs mimic those reported in humans with pathogenic SCN9A variants causing CIP. This report is the first of a spontaneous pathogenic SCN9A variant in domestic animals.

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Canis lupus familiaris,animal model,genetics,neurology,precision medicine,sodium channel

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