Conventional type 1 dendritic cells protect against gut barrier disruption via maintaining Akkermansia muciniphila in alcoholic steatohepatitis.

Liuyi Hao,Wei Zhong,Jongmin Woo,Xiaoyuan Wei,Hao Ma,Haibo Dong,Wei Guo,Xinguo Sun,Ruichao Yue,Jiangchao Zhao,Qibin Zhang,Zhanxiang Zhou

Hepatology (Baltimore, Md.)（2023）

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摘要

This study demonstrated that cDC1s protect alcohol-induced liver injury by maintaining A. muciniphila abundance in mice. Targeting cDC1s may serve as a promising therapeutic approach for treating ALD.

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关键词

dendritic cells,akkermansia muciniphila,gut barrier disruption

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