In vivo overexpression of synaptogyrin-3 promotes striatal synaptic dopamine uptake in LRRK2 R1441G mutant mouse model of Parkinson's disease.

Philip Wing-Lok Ho,Lingfei Li,Hui-Fang Liu,Zoe Yuen-Kiu Choi,Eunice Eun Seo Chang,Shirley Yin-Yu Pang,Yasine Malki,Chi-Ting Leung,Michelle Hiu-Wai Kung,David Boyer Ramsden,Shu-Leong Ho

Brain and behavior（2023）

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摘要

Brain SYNGR3 expression may be an important determinant to striatal DA homeostasis and synaptic function. Our preliminary behavioral test showed improved innate behavior after SYNGR3 overexpression in LRRK2 mutant mice, advocating further studies to determine the influence of SYNGR3 in the pathophysiology of DA neurons in PD.

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关键词

LRRK2 mutation,SYNGR3,behavioral test,dopamine uptake

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