A New Insight Into p53-Inhibiting Genes in Epstein–Barr Virus-Associated Gastric Adenocarcinoma

Seyed Mohammad Ali Hashemi,Abdolvahab Moradi,Seyed Younes Hosseini,Hadi Razavi Nikoo,Taravat Bamdad,Zahra Faghih,Jamal Sarvari,Alijan Tabarraei

Iranian biomedical journal（2023）

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摘要

EBNA1 enhances the expression of p53-inhibiting genes. Two events—p53 protein overexpression and apoptosis activation—followed the suppression of the USP7 protein and provided evidence for its possible function. The significance of the EBNA1-USP7 interaction in p53 suppression warrants additional investigation and possibly reconsideration.

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关键词

Herpesvirus 4,Tumor suppressor protein p53,USP7 protein

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