Epidemiology, antimicrobial resistance, and mortality risk factors of carbapenem resistant gram-negative bacteria in hematopoietic stem cell transplantation recipients.

The crude infection rate of CRGNB in HSCT recipients was 7.42%, and the mortality rate was 47.1%. CRGNB was resistant to most commonly used antibiotics. Time interval from diagnosis to transplantation >180 days (HR=7.886, 95% CI 2.624-23.703, =0.000), septic shock (HR=6.182, 95% CI 2.605-14.671, =0.000), platelet count < 20 × 10/L (HR=2.615, 95% CI 1.152-5.934, =0.022) and total bilirubin > 34.2 μmol/L (HR=7.348, 95% CI 2.966-18.202, =0.000) at the initial stage of infection were 4 independent risk factors associated with mortality. CRGNB infection has become a serious threat to HSCT recipients. Clinicians should pay high attention to it and actively seek personalized treatment strategies suitable for local medical conditions.