Interference of neuronal TrkB signaling by the cannabis-derived flavonoids cannflavins A and B

•Flavonoids derived from Cannabis sativa, cannflavin A and cannflavin B, inhibit the activation of Tropomyosin receptor kinase B (TrkB) in primary cortical neurons.•Minimal doses of cannflavins (10 μM) disrupt downstream signaling of TrkB receptors, reducing the accumulation of Activity-regulated cytoskeleton-associated (Arc) protein.•Cannflavins at 10 μM block cellular processes in TrkB stably expressing neuroblastoma cell line.