Modeling of restenosis on implanted intra-arterial stent in experimental cardiology

Aim of investigation is to study the features of the mechanism of restenosis on implanted intravascular stent, using the original device for modeling of intra-arterial circulation. Materials and methods. We use an original device for modeling intra-arterial circulation (document of invention RU 202780). It is a simulation of arterial vessel, made of glass tube rotameter. Its free ends are connected with two silicone tubes, with other ends - to the pump, powered by a 12 Volt battery. We injected the fluid (an aqueous solution of glycerin) into the closed system, diluted corresponding to the viscosity of human blood. A fitting is located at the inlet end of the tube, through which we can introduce a dye (ink), a silk thread or intravascular pressure probe inside the tube. Results. As a prototype of intravascular endoprosthesis, we used a metal device 71 mm length, made in the form of a grid with beams directed in a spiral. We installed a conductor with a 5 cm long silk thread inside the endoprosthesis. The pump works simulating the regular heart rhythm or premature ventricular contractions. We observed an intense pressure effect of the first post-extrasystolic wave on the rotameter tube, with the formation of reflected, standing waves (the pressure increased by 160% compared with the regular heart rhythm). Conclusion. With the spread of the first post-extrasystolic wave, a "hydraulic shock" occurs in the arterial vessel. Its mechanical effect can be the starting point for the onset and progression of restenosis in an implanted intravascular stent.