SGK1 Inhibition Attenuated the Action Potential Duration In-Patient and Genotype-Specific Re-Engineered Heart Cells With Congenital Long QT Syndrome

David J. Tester,Saumya Das,Maengjo Kim,Sabindra Pradhananga,Samantha K. Hamrick,Dinesh Srinivasan,Philip Sager,Michael J. Ackerman

CIRCULATION（2022）

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摘要

Therapeutically inhibiting SGK1 effectively shortens the APD in human iPSC-CM models of the 3 major LQTS genotypes. These preclinical data support development of SGK1 inhibitors as novel, first-in-class therapy for patients with congenital LQTS.

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关键词

Long QT syndrome,Serum and glucocorticoid regulated kinase-1,SGK1,Treatment,Therapeutic,iPSC

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