Neoadjuvant camrelizumab plus chemotherapy in patients with locally advanced cervical cancer (NACI): A prospective, single-arm, phase II trial

Neoadjuvant chemotherapy (NACT) is an emerging approach for locally advanced cervical cancer (LACC), while two-thirds of patients (pts) respond to it and pts without response benefit little. PD-1 inhibitors have exhibited promising role in recurrent or metastatic cervical cancer. Additionally, preclinical evidence for the activation and synergistic effects of NACT on PD-1 inhibitors supports the superiority of neoadjuvant immunotherapy. We designed this phase II study to evaluated the efficacy and safety of preoperative PD-1 inhibitor camrelizumab combined chemotherapy in pts with LACC.