Substrate binding in the mitochondrial ADP/ATP carrier is a step-wise process guiding the structural changes in the transport cycle

Vasiliki Mavridou,Martin S. King,Sotiria Tavoulari,Jonathan J. Ruprecht,Shane M. Palmer,Edmund R. S. Kunji

Nature Communications（2022）

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摘要

The mitochondrial ADP/ATP carrier transports adenine nucleotides. Here, authors identify the residues involved in substrate binding. One set forms the central substrate binding site and two asparagine/arginine pairs help to guide the substrates during the transport cycle.

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