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TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p

Jonathan Berrout,Eleni Kyriakopoulou,Lavanya Moparthi,Alexandra S. Hogea,Liza Berrout,Cristina Ivan,Mihaela Lorger,John Boyle,Chris Peers,Stephen Muench,Jacobo Elies Gomez,Xin Hu,Carolyn Hurst,Thomas Hall,Sujanitha Umamaheswaran,Laura Wesley,Mihai Gagea,Michael Shires,Iain Manfield,Margaret A. Knowles,Simon Davies,Klaus Suhling,Yurema Teijeiro Gonzalez,Neil Carragher,Kenneth Macleod,N. Joan Abbott,George A. Calin,Nikita Gamper,Peter M. Zygmunt,Zahra Timsah

Nature Communications（2017）

引用 38|浏览7
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摘要
TRPA1 has been reported to contribute lung cancer adenocarcinoma (LUAD), but the mechanisms are unclear. Here the authors propose that TRPA1/FGFR2 interaction is functional in LUAD and show that astrocytes oppose brain metastasis by mediating the downregulation of TRPA1 through exosome-delivered miRNA-142-3p.
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