HIV-1 Genomes Are Enriched in Memory CD4 ⁺ T-Cells with Short Half-Lives

Vincent Morcilla,Charline Bacchus-Souffan,Katie Fisher,Bethany A. Horsburgh,Bonnie Hiener,Xiao Qian Wang,Timothy E. Schlub,Mark Fitch,Rebecca Hoh,Frederick M. Hecht,Jeffrey N. Martin,Steven G. Deeks,Marc K. Hellerstein, Joseph M. McCune,Peter W. Hunt,Sarah Palmer

mBio（2021）

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摘要

The design of future HIV-1 curative therapies requires a more thorough understanding of the distribution of genetically intact HIV-1 within T-cell subsets as well as the cellular mechanisms that maintain this reservoir. These genetically intact and presumably replication-competent proviruses make up the latent HIV-1 reservoir.

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HIV-1 Genomes Are Enriched in Memory CD4 + T-Cells with Short Half-Lives

HIV-1 Genomes Are Enriched in Memory CD4 ⁺ T-Cells with Short Half-Lives