Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases

Adrien Georges,Min-Lee Yang,Takiy-Eddine Berrandou,Mark K. Bakker,Ozan Dikilitas,Soto Romuald Kiando,Lijiang Ma,Benjamin A. Satterfield,Sebanti Sengupta,Mengyao Yu,Jean-François Deleuze,Delia Dupré,Kristina L. Hunker,Sergiy Kyryachenko,Lu Liu,Ines Sayoud-Sadeg,Laurence Amar,Chad M. Brummett,Dawn M. Coleman,Valentina d’Escamard,Peter de Leeuw,Natalia Fendrikova-Mahlay,Daniella Kadian-Dodov,Jun Z. Li,Aurélien Lorthioir,Marco Pappaccogli,Aleksander Prejbisz,Witold Smigielski,James C. Stanley,Matthew Zawistowski,Xiang Zhou,Sebastian Zöllner, FEIRI investigators,International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group, MEGASTROKE,Philippe Amouyel,Marc L. De Buyzere,Stéphanie Debette,Piotr Dobrowolski,Wojciech Drygas,Heather L. Gornik,Jeffrey W. Olin,Jerzy Piwonski,Ernst R. Rietzschel,Ynte M. Ruigrok,Miikka Vikkula,Ewa Warchol Celinska,Andrzej Januszewicz,Iftikhar J. Kullo,Michel Azizi,Xavier Jeunemaitre,Alexandre Persu,Jason C. Kovacic,Santhi K. Ganesh,Nabila Bouatia-Naji

Nature Communications（2021）

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摘要

Fibromuscular dysplasia is a cardiovascular disease affecting mostly women with a mostly unknown genetic basis. Here the authors have performed a genome-wide association meta-analysis of Fibromuscular dysplasia to identify genetic loci, some of which are shared with common cardiovascular disease and traits.

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