High flow cooled air can decrease brain temperature without injuring the snout or brain in Swine

•What is already known on this topic: Targeted temperature management is an important part of medical practice with multiple applications in trauma and surgery.•What this study adds: Safety and efficacy data for a novel device that performs isolated brain cooling.•How this study might affect research, practice, or policy: This study describes using high flow cooled air for isolated brain cooling & provides data to support regulatory evaluation.