Circulating neutrophils and tumor-associated myeloid cells function as a powerful biomarker for response to chemoradiation in locally advanced cervical cancer.

Olsi Gjyshi, Adam Grippin,Lauren Andring,Anuja Jhingran,Lilie L. Lin,Julianna Bronk,Patricia J. Eifel,Melissa M. Joyner,Jagannadha K. Sastry,Kyoko Yoshida-Court,Travis N. Solley,Tatiana Cisneros Napravnik, Madison P. O'Hara,Venkatesh L Hegde,Lauren E. Colbert,Ann H Klopp

Clinical and translational radiation oncology（2023）

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摘要

These findings identify on-treatment mean neutrophil count as a predictor of disease-related outcomes, suggest that neutrophils contribute to chemoradiation treatment resistance, and demonstrate the importance of techniques to measure intratumoral immune activity.

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关键词

Biomarker,Cervical cancer,Immunobiology,Neutrophils,Radiation oncology

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