Navitoclax improves acute-on-chronic liver failure by eliminating senescent cells in mice.

Yusuke Watanabe,Hiroyuki Abe,Naruhiro Kimura,Yoshihisa Arao,Natsuki Ishikawa, Maeda Yuichiro,Toru Setsu,Akira Sakamaki,Hiroteru Kamimura,Takeshi Yokoo,Kenya Kamimura,Atsunori Tsuchiya,Shuji Terai

Hepatology research : the official journal of the Japan Society of Hepatology（2023）

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摘要

Navi may ameliorate ACLF damage by eliminating senescent cells in the liver, downregulating SASP factors, and upregulating mitochondrial functions. We believe that this novel approach using Navi will pave the way for ACLF treatment. This article is protected by copyright. All rights reserved.

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关键词

Acute-on-chronic liver failure,Mitochondrial function,Navitoclax,Senescence-associated secretory phenotype

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