Adeno-associated virus vector intraperitoneal injection induces colonic mucosa and submucosa transduction and alters the diversity and composition of the faecal microbiota in rats.

Li-Tian Ma,Jing-Xuan Lian, Yang Bai, Meng-Juan Shang, Zhe-Zhe Zhang, Fei-Fei Wu, Jing Chen, Xian-Bo Meng,Jin Zheng,Tian Li, Yun-Qing Li,Jing-Jie Wang

Frontiers in cellular and infection microbiology（2022）

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摘要

In summary, these data show that IP injection of AAV9 can successfully induce the transduction of the colonic mucosa and submucosa and alter the diversity and composition of the faecal microbiota in rats.

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关键词

16S rRNA,adeno-associated virus vector (AAV),diversity,faecal microbiota,gene therapy

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