eNAMPT/TLR4 inflammatory cascade activation is a key contributor to SLE Lung vasculitis and alveolar hemorrhage

Gantsetseg Tumurkhuu,Nancy G Casanova,Carrie L Kempf,Duygu Ercan Laguna,Sara M Camp,Jargalsaikhan Dagvadorj,Jin H Song,Vivian Reyes Hernon,Cristina Travelli,Erica N Montano,Jeong Min Yu,Mariko Ishimori,Daniel J Wallace,Saad Sammani,Caroline Jefferies,Joe G N Garcia

Journal of Translational Autoimmunity（2023）

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摘要

•eNAMPT is a highly druggable DAMP and biomarker involved in the pathobiology of SLE.•eNAMPT/TLR4 inflammatory signaling is intimately linked to pulmonary vasculitis.•A eNAMPT-neutralizing mAb is highly effective in reducing lupus vasculitis severity.

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关键词

eNAMPT,DAMP,SLE,Pulmonary vasculitis,DAH,Pristane

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