Metagenomic and bile acid metabolomic analysis of fecal microbiota transplantation for recurrent Clostridiodes difficile and/or inflammatory bowel diseases.

Rubin Jf Ramos,Chencan Zhu,Dimitri F Joseph,Shubh Thaker,Joseph F Lacomb, Katherine Markarian,Hannah J Lee,Jessica C Petrov,Farah Monzur,Jonathan M Buscaglia,Anupama Chawla, Leslie Small-Harary,Grace Gathungu, Jeffrey A Morganstern,Jie Yang,Jinyu Li,Eric G Pamer,Charles E Robertson,Daniel N Frank,Justin R Cross,Ellen Li

Medical research archives（2022）

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摘要

Restoration of multiple secondary BA levels, including BA epimers implicated in immunoregulation, are associated with restoration of fecal baiE gene counts, suggesting that the 7-α-dehydroxylation step is rate-limiting.

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关键词

fecal microbiota transplantation,bile acid metabolomic analysis,recurrent clostridiodes difficile

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